About InnoPran XL

Consider InnoPranXL™ for your patients with hypertension who need the added control of a beta-blocker

• For the efficacy of a beta-blocker with fatigue rate similar to placebo at 80mg
• An innovative delivery system: PM dose, AM Peak
• Convenient, once-daily bedtime dose leads to peak plasma levels in the AM
  

The capsules contain sustained-release beads available as 80 mg and 120 mg capsules.

Please click on the links below for more information about InnoPran XL.

• 24-hour efficacy
• Fatigue rate similar to placebo at the 80-mg dose
• Innovative timed delivery system
• PM dose, AM peak
• Patients with hypertension

Important Safety Information

Patients taking InnoPran XL™ should be advised against abrupt interruption or cessation of therapy without their physician’s advice. Exacerbation of angina, and in some cases myocardial infarction, have been reported following abrupt discontinuance or propranolol therapy. Dosage should be gradually reduced over at least a few weeks.

Metabolism of propranolol involves multiple pathways in the cytochrome system P-450 (CYP2D6, 1A2, 2C19) which could potentially lead to drug-drug interactions. Please consult the prescribing information for a list of interaction information.

InnoPran XL is contraindicated in patients with cardiogenic shock; sinus bradycardia, greater than first-degree AV block; and in patients with bronchial asthma or with known hypersensitivity to propranolol hydrochloride.

With InnoPran XL the most common side effects were fatigue 5% vs. 3%, dizziness 7%vs. 2%, and constipation 3% vs. 0%.

Therapeutic blood levels do not necessarily correlate with efficacy.