Studies have demonstrated that blood pressure rises and falls at different times of the day1.

In general, your blood pressure and heart rate will be lower while you sleep and will begin to rise when you get out of bed. This natural fluctuation is known as circadian rhythm.

Morning rises in blood pressure are normal. But for patients with hypertension, rapid surges in morning blood pressure can cause problems. Morning surges in blood pressure have been associated with increased incidence of heart attack and stroke.


1. Elliott WJ; Cyclic and Circadian Variations in Cardiac Events; Am Jour of Hypertension, 2001; 14:291S-295S

Image of heart with blood pressure numbers

Your healthcare provider has many options in terms of medication that he or she can prescribe to control your blood pressure. Most blood pressure medications are taken once daily. Most do not reach their peak effect during the morning (6 am – 12 pm) even when they are taken at night.

InnoPran XL® is designed to reach its peak effect in the early morning hours so that it can offset the rise in blood pressure at that time of day. When you take InnoPran XL® as directed every evening at bedtime — around 10 pm is recommended — you may get the maximum protection in the morning. And because InnoPran XL® is a timed-release medication, it will keep working for 24 hours to keep your blood pressure under control all day.*

To learn more about high blood pressure and the risks of early morning surges for heart attacks and strokes, speak to your healthcare provider about InnoPran XL®.

* Individual results may vary.

InnoPran XL® is a prescription medication. As with all prescription medications, you should follow your healthcare provider’s guidance and ask him/her if you have any questions when taking InnoPran XL®. Here are some important tips for taking InnoPran XL®:

  • Take one capsule of InnoPran XL® daily. Do not take more than one capsule daily without your physician’s knowledge and direction. Take it at night — around 10 pm is recommended. You can take your daily capsule with food or on an empty stomach.

  • Do not stop taking InnoPran XL® without consulting with your physician first. Some patients who suddenly stop taking InnoPran XL® may be at increased risk of chest pain or heart attack. Your healthcare provider will let you know the safest way to gradually reduce the dose over a few weeks.

  • Let your healthcare provider and pharmacist know about all the other medicines you are taking, including supplements and over the counter medicines, so that they can check for potential interactions between InnoPran XL® and your other medications.

  • Make sure your healthcare provider knows your medical history. InnoPran XL® is not recommended for patients who have been previously diagnosed with a certain type of arrhythmia or with bronchial asthma or COPD. Let your healthcare provider know if you have ever had problems taking propranolol, the major ingredient in InnoPran XL®.

  • Store your InnoPran XL® in a cool, dry place where it will be secure.

Blood pressure is determined by the amount of blood your heart pumps and the amount of resistance to blood flow in your arteries. The more blood your heart pumps and the narrower your arteries, the higher your blood pressure. Uncontrolled high blood pressure can increase your risk for serious health problems like heart attack and stroke.

High blood pressure is a common condition. Millions of Americans suffer from it. Generally, high blood pressure develops over many years. Since there are usually no symptoms, you may not know that you have high blood pressure it until you are diagnosed. Fortunately, there are treatment options.

Image of doctor checking patients blood pressure

When your healthcare professional measures your blood pressure, he or she will tell you two numbers: systolic and diastolic blood pressure. As an example, you may be told that your blood pressure is 110 over 80. This means that your systolic blood pressure is 110 and your diastolic blood pressure is 80. So what does this mean?

Systolic Blood Pressure

Systolic blood pressure is the amount of pressure that blood exerts on arteries and vessels while the heart is beating. Systolic comes from the ancient Greek word “systole” which means “a drawing together or a contraction.” The normal range for systolic blood pressure is 90 – 120 mmHg in adults. Your systolic blood pressure measurement becomes more important as you age.

Diastolic Blood Pressure

Diastolic blood pressure is the pressure that is exerted on the walls of the various arteries around the body in between heart beats when the heart is relaxed. Diastolic comes from the ancient Greek word “diastole’ which means “a drawing apart.” Diastolic blood pressure represents the minimum blood pressure in the arteries. The normal range for diastolic blood pressure is between 60 – 80 mmHg in adults.

Image of blood pressure cuff

The importance of your systolic vs. your diastolic blood pressure largely depends on your age and your other health conditions. According to a recent study published in the Journal of General Internal Medicine, if you’re under the age of 50 a high diastolic blood pressure is a better predictor of early mortality than an elevated systolic blood pressure. The opposite is true if you’re over the age of 50 when a high systolic pressure becomes the best predictor of early death.1 This doesn’t mean that if you’re over the age of 50 a high diastolic blood pressure isn’t important anymore – it is. High diastolic blood pressure can also increase the risk of dying early, but it’s not the best predictor of future health problems and death.

Your blood pressure measurements must be taken in context with your overall health. If you’ve been diagnosed with diabetes or if you have suffered a stroke, the importance of your systolic blood pressure reading may be more important to you than your diastolic reading. For this reason, it is wise to discuss the components of your blood pressure (systolic vs. diastolic) with your healthcare provider to understand what each may mean specifically for you.


1. Taylor, B, Wilt, T et al; “Impact of Diastolic and Systolic Blood Pressure on Mortality: Implications for the Definition of ‘Normal’ “; Journal of General Internal Medicine; July, 2011; vol 26 (7); pp 685- 690

Image of electronic blood pressure cuff

High blood pressure can have severe health consequences. The higher your blood pressure and the longer it goes uncontrolled, the more severe these consequences can be. High blood pressure is a risk factor for the following conditions, as well as others:

  • Heart attack

  • Stroke

Please consult with your healthcare provider for further information on the consequences of high blood pressure.

Image of blood pressure signs

In addition to taking your blood pressure medication as directed, you can make the following changes to your lifestyle to help control your condition:

  • Eat healthy foods.

  • Reduce your intake of salt.

  • Maintain a healthy weight.

  • Increase your physical activity.

  • Limit the amount of alcohol.

  • Stop smoking.

  • Monitor your blood pressure.

Please consult with your healthcare provider for more information on changes to your lifestyle.

Image of fruit and electronic blood pressure cuff

In Hypertension, InnoPran XL® is Designed to… Take on the Surge

Healthcare providers have known for years that blood pressure and heart rate surge in the morning hours (6 am – 12 pm) as you wake up. Until recently, the effects of these surges in blood pressure were not clearly understood. Recent clinical studies have demonstrated that an increase in the risk of heart attack and stroke that also occurs in the morning hours. InnoPran XL® is a circadian-aligned beta-blocker therapy that can help you to manage your blood pressure and reduce the risk of heart attack and stroke. Learn here about hypertension and how one bedtime dose of InnoPran XL® can help you Take on the Surge of morning blood pressure and manage your hypertension for a full 24 hours.

Image of human with heartbeat

INDICATION: InnoPran XL® is a beta adrenergic blocker indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.

LIMITATION OF USE: InnoPran XL® is not indicated for the treatment of hypertensive emergencies.

Important Safety Information About InnoPran XL®

What is InnoPran XL®?

InnoPran XL® is a prescription medicine that belongs to a group of medicines called “beta blockers” used to treat high blood pressure. InnoPran XL® lowers blood pressure, which can reduce the risk of strokes and heart attack. InnoPran XL® is not to be used to treat high blood pressure emergencies.

What is the most important information I should know about InnoPran XL® (propranolol)?

WARNING: Do not stop taking InnoPran XL® suddenly, as heart attacks and worsening of chest pain have occurred. If your doctor decides you should stop taking InnoPran XL®, you may be instructed to slowly reduce your dose over a period of time before stopping it completely.

Do not use InnoPran XL® if you have:

  • Abnormal heart rhythms caused by a malfunction of the heart’s primary pacemaker, unless a permanent pacemaker is in place
  • Sudden and severe drop in blood pressure and blood flow through the body because the heart is not pumping normally
  • Uncontrolled heart failure
  • Asthma
  • Any allergies to InnoPran XL® ingredients. The active ingredient is propranolol.

What should I tell my healthcare provider before taking InnoPran XL®?

Before starting InnoPran XL®, tell your healthcare provider about all of your medical conditions, including if you:

  • Have heart failure
  • Are scheduled for surgery and will be given anesthetic agents
  • Have diabetes and take medicine to control blood sugar
  • Have thyroid problems
  • Have irregular heartbeats
  • Have liver or kidney problems
  • Have had allergic reactions to medications or have allergies
  • Have asthma or other lung problems (such as bronchitis or emphysema)
  • Are pregnant or trying to become pregnant. It is not known if InnoPran XL® is safe for your unborn baby. Talk with your doctor about the best way to treat your high blood pressure during pregnancy.
  • Are breastfeeding. You should not breastfeed while using InnoPran XL® because the drug is passed to the infant through the mother’s milk.

Tell your healthcare provider about all of the prescription or over-the-counter medications, vitamins, or herbal supplements you are taking including:

  • Wafarin
  • Propafenone
  • Other beta blockers and alpha blockers such as: clonidine (Catapres, Kapvay, Nexiclon), prazosin (Minipress, Vasoflex, Lentopres and Hypovase)
  • The heart failure drug dobutamine
  • Antidepressants
  • Non-steroidal anti-inflammatory drugs (NSAIDS) for pain relief, fever reduction, and reducing inflammation including over-the-counter ibuprofen (e.g. Advil, Motrin)

This list is not complete and not all possible interactions are listed. Other drugs may interact with InnoPran XL®, including prescription and over-the-counter medicines, vitamins, and herbal products.

What are the possible side effects of InnoPran XL®?

The most common side effects people taking InnoPran XL® report are tiredness, dizziness (if you feel dizzy, sit or lie down and tell your doctor right away), and constipation.

Other possible side effects include difficulty breathing, tightness in the chest, heart failure, hiding symptoms of low blood sugar and overactive thyroid, especially a fast heartbeat, and certain abnormal heart rhythms.

This is not a complete list of side effects and others may occur. Click here to see the Full Prescribing Information for more detailed information. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other information do I need to know about taking InnoPran XL®?

  • InnoPran XL® should be taken orally.
  • InnoPran XL® should be taken consistently with or without food.
  • Do not stop taking InnoPran XL® suddenly. You could have chest pain or a heart attack. If your doctor decides that you should stop taking InnoPran XL®, he or she will lower your dose slowly and over time.
  • Take InnoPran XL® every day at bed time or exactly as your doctor tells you. Your doctor will tell you how much InnoPran XL® to take and how often. Your doctor may start with a low dose and raise it over time.
  • Do not stop taking InnoPran XL® or change your dose without talking with your doctor.
  • Do not drive or use machinery until you are sure you can perform activities safely.
  • If you have heart failure, consult your physician if you experience weight gain or increasing shortness of breath.
  • If you have diabetes, consult your physician if you experience changes in your blood sugar levels.
  • People taking InnoPran XL® may be less responsive to epinephrine used to treat a severe anaphylactic reaction.
  • If you take too much InnoPran XL® call your doctor or poison control center right away.

Please also see full Prescribing Information for more information.

InnoPran XL® is a registered trademark of ANI Pharmaceuticals, Inc. Marketed and distributed by: ANI Pharmaceuticals, Inc.
InnoPran XL®, a DIFFUCAPS® drug delivery product manufactured by Adare Pharmaceuticals, Inc., Vandalia, OH 45377

*Terms and conditions

Offer not valid for any individual for whom any part of InnoPran XL® prescription is or will be covered by Medicaid, Medicare (including Medicare Advantage or Part D Prescription Plans), any state prescription drug programs, or any other public payer program.

  • This program cannot be combined with any other coupon certificate, voucher or similar offer.
  • Offer applies to out-of-pocket (OOP) expenses for InnoPran XL®. Out-of-pocket expenses greater than $0 will be covered up to a maximum of $300 per prescription of actual out-of-pocket expenses (a) per 30-day supply for each of up to twelve (12) prescription fills, (b) per 60-day supply for each of up to six (6) prescription fills, or (c) per 90-day supply for each of up to four (4) prescription fills.
  • Offer good only in the USA and Puerto Rico at participating retail pharmacies and cannot be redeemed at government-subsidized clinics.
  • ANI Pharmaceuticals, Inc. reserves the right to rescind, revoke or amend this offer without notice.
  • Participation in this program must comply with all applicable state laws and contractual or other obligations as a pharmacy provider.
  • This is not an insurance program.
  • Participating patients and pharmacists understand and agree to comply with the terms and conditions of this offer as set forth herein.
  • Offer not extended for prescriptions for:
    • No claims paid by Government-sponsored insurance plans
      • Medicare, Medicaid, Federal, State, Patient Pharmaceutical Assistance
    • No Pharmacies in states that prohibit the offering of co-pay assistance at the point of dispensing
    • Patients 17 years of age and younger are excluded
    • No cash claims

To find a participating eVoucherRx™ pharmacy visit: