In hypertension, InnoPran XL trademark is designed to take on the surge. Footnotes one, two. Chart
  • Timed-release circadian-aligned beta-blocker
  • Reduce risk of MI and cardio-ischemic events2
  • Propanolol is highly lipophilic and better able to cross the blood-brain barrier than other beta-blockers3,4
  • Simple bedtime dosing
  • Available in 80mg and 120mg doses by prescription only
  • InnoPran XL® is not indicated for the treatment of hypertensive emergencies


1. Muller JE. Circadian variation and triggering of acute coronary events. Am Heart J. 1999;137(4 pt 2):S1-S8.

2. Elliot WJ. Cyclic and circadian variations in cardiovascular events. Am J Hypertens. 2001;14(9 pt 2):291S-295S.

3. Gulyaeva N, Zaslavsky A, Lechner P, Chlenov M, Chait A, Zaslavsky B. RelaIve hydrophobicity and lipophilicity of betablockers and related compounds as measured by aqueous two-phase parIIoning, octanol-buffer parIIoning, and HPLC. Eur J Pharm. 2002;17(1-2):81-93.

4. Neil-Dwyer G, BartleF J, McAinsh J, Cruickshank JM. Beta-adrenoceptor blockers and the blood-brain barrier. Br J Clin Pharmacol. 1981;11(6):549-553.

INDICATION: InnoPran XL® is a beta adrenergic blocker indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.

LIMITATION OF USE: InnoPran XL® is not indicated for the treatment of hypertensive emergencies.

Important Safety Information About InnoPran XL®

What is InnoPran XL®?

InnoPran XL® is a prescription medicine that belongs to a group of medicines called “beta blockers” used to treat high blood pressure. InnoPran XL® lowers blood pressure, which can reduce the risk of strokes and heart attack. InnoPran XL® is not to be used to treat high blood pressure emergencies.

What is the most important information I should know about InnoPran XL® (propranolol)?

WARNING: Do not stop taking InnoPran XL® suddenly, as heart attacks and worsening of chest pain have occurred. If your doctor decides you should stop taking InnoPran XL®, you may be instructed to slowly reduce your dose over a period of time before stopping it completely.

Do not use InnoPran XL® if you have:

  • Abnormal heart rhythms caused by a malfunction of the heart’s primary pacemaker, unless a permanent pacemaker is in place
  • Sudden and severe drop in blood pressure and blood flow through the body because the heart is not pumping normally
  • Uncontrolled heart failure
  • Asthma
  • Any allergies to InnoPran XL® ingredients. The active ingredient is propranolol.

What should I tell my healthcare provider before taking InnoPran XL®?

Before starting InnoPran XL®, tell your healthcare provider about all of your medical conditions, including if you:

  • Have heart failure
  • Are scheduled for surgery and will be given anesthetic agents
  • Have diabetes and take medicine to control blood sugar
  • Have thyroid problems
  • Have irregular heartbeats
  • Have liver or kidney problems
  • Have had allergic reactions to medications or have allergies
  • Have asthma or other lung problems (such as bronchitis or emphysema)
  • Are pregnant or trying to become pregnant. It is not known if InnoPran XL® is safe for your unborn baby. Talk with your doctor about the best way to treat your high blood pressure during pregnancy.
  • Are breastfeeding. You should not breastfeed while using InnoPran XL® because the drug is passed to the infant through the mother’s milk.

Tell your healthcare provider about all of the prescription or over-the-counter medications, vitamins, or herbal supplements you are taking including:

  • Wafarin
  • Propafenone
  • Other beta blockers and alpha blockers such as: clonidine (Catapres, Kapvay, Nexiclon), prazosin (Minipress, Vasoflex, Lentopres and Hypovase)
  • The heart failure drug dobutamine
  • Antidepressants
  • Non-steroidal anti-inflammatory drugs (NSAIDS) for pain relief, fever reduction, and reducing inflammation including over-the-counter ibuprofen (e.g. Advil, Motrin)

This list is not complete and not all possible interactions are listed. Other drugs may interact with InnoPran XL®, including prescription and over-the-counter medicines, vitamins, and herbal products.

What are the possible side effects of InnoPran XL®?

The most common side effects people taking InnoPran XL® report are tiredness, dizziness (if you feel dizzy, sit or lie down and tell your doctor right away), and constipation.

Other possible side effects include difficulty breathing, tightness in the chest, heart failure, hiding symptoms of low blood sugar and overactive thyroid, especially a fast heartbeat, and certain abnormal heart rhythms.

This is not a complete list of side effects and others may occur. Click here to see the Full Prescribing Information for more detailed information. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other information do I need to know about taking InnoPran XL®?

  • InnoPran XL® should be taken orally.
  • InnoPran XL® should be taken consistently with or without food.
  • Do not stop taking InnoPran XL® suddenly. You could have chest pain or a heart attack. If your doctor decides that you should stop taking InnoPran XL®, he or she will lower your dose slowly and over time.
  • Take InnoPran XL® every day at bed time or exactly as your doctor tells you. Your doctor will tell you how much InnoPran XL® to take and how often. Your doctor may start with a low dose and raise it over time.
  • Do not stop taking InnoPran XL® or change your dose without talking with your doctor.
  • Do not drive or use machinery until you are sure you can perform activities safely.
  • If you have heart failure, consult your physician if you experience weight gain or increasing shortness of breath.
  • If you have diabetes, consult your physician if you experience changes in your blood sugar levels.
  • People taking InnoPran XL® may be less responsive to epinephrine used to treat a severe anaphylactic reaction.
  • If you take too much InnoPran XL® call your doctor or poison control center right away.

Please also see full Prescribing Information for more information.

InnoPran XL® is a registered trademark of ANI Pharmaceuticals, Inc. Marketed and distributed by: ANI Pharmaceuticals, Inc.
InnoPran XL®, a DIFFUCAPS® drug delivery product manufactured by Adare Pharmaceuticals, Inc., Vandalia, OH 45377

*Terms and conditions

Offer not valid for any individual for whom any part of InnoPran XL® prescription is or will be covered by Medicaid, Medicare (including Medicare Advantage or Part D Prescription Plans), any state prescription drug programs, or any other public payer program.

  • This program cannot be combined with any other coupon certificate, voucher or similar offer.
  • Offer applies to out-of-pocket (OOP) expenses for InnoPran XL®. Out-of-pocket expenses greater than $0 will be covered up to a maximum of $300 per prescription of actual out-of-pocket expenses (a) per 30-day supply for each of up to twelve (12) prescription fills, (b) per 60-day supply for each of up to six (6) prescription fills, or (c) per 90-day supply for each of up to four (4) prescription fills.
  • Offer good only in the USA and Puerto Rico at participating retail pharmacies and cannot be redeemed at government-subsidized clinics.
  • ANI Pharmaceuticals, Inc. reserves the right to rescind, revoke or amend this offer without notice.
  • Participation in this program must comply with all applicable state laws and contractual or other obligations as a pharmacy provider.
  • This is not an insurance program.
  • Participating patients and pharmacists understand and agree to comply with the terms and conditions of this offer as set forth herein.
  • Offer not extended for prescriptions for:
    • No claims paid by Government-sponsored insurance plans
      • Medicare, Medicaid, Federal, State, Patient Pharmaceutical Assistance
    • No Pharmacies in states that prohibit the offering of co-pay assistance at the point of dispensing
    • Patients 17 years of age and younger are excluded
    • No cash claims

To find a participating eVoucherRx™ pharmacy visit: